JoyToKey does not seem to work on Windows Vista, 7, 8 or 10
JoyToKey may not be able to control certain softwares on Windows Vista or later due to an enhanced security control. If you encounter such cases, please try to launch JoyToKey.exe by opening right-click popup menu and select “Run as administrator”. Alternatively, you can also try “Use XP compatible mode” in the same popup menu.
NOTE: On Windows 8 or later, emulation of certain shortcuts (such as Alt-TAB) does not work unfortunately due to a new design (restriction) of Windows security policy from Microsoft. At this moment, there is no known way to make it work from JoyToKey.